Only once did David Foster Wallace give a public talk on his views on life, during a commencement address given in 2005 at Kenyon College. The speech is reprinted for in book form in THIS IS WATER. How does one keep from going through their comfortable, prosperous adult life unconsciously? How do we get ourselves out of the foreground of our thoughts and achieve compassion? The speech captures Wallace’s electric intellect as well as his grace in attention to others. After his death, it became a treasured piece of writing reprinted in The Wall Street Journal and the London Times, commented on endlessly in blogs, and emailed from friend to friend.
It was the first time I heard this powerful speech this morning ~ hat tip Maria Popova who posted it on Brain Pickings today ~ if you have never heard it, take time out and listen – it blew me away!
“This is the first time that researchers have been able to identify a brain process directly responsible for the beneficial effects of exercise in slowing down the progression of the early memory decline characteristics of Alzheimer’s disease,” says Marie-Christine Pardon. Image:Stockxpert
A stress hormone produced during moderate exercise may protect the brain from memory changes related to Alzheimer’s disease.
The findings, published in the Journal of Alzheimer’s Disease by researchers from the University of Nottingham, may also explain why people who are susceptible to stress are at more risk of developing the disease.
Increasingly there is evidence that physical and mental activity can reduce people’s chances of developing the disease or can slow down its progression but until now it has been unclear how this happens.
A research team, led by Marie-Christine Pardon in the School of Biomedical Sciences, discovered that the stress hormone CRF—or corticotrophin-releasing factor—may have a protective effect on the brain from the memory changes brought on by Alzheimer’s disease.
CRF is most associated with producing stress and is found in high levels in people experiencing some forms of anxiety and depressive diseases. Normal levels of CRF, however, are beneficial to the brain, keeping the mental faculties sharp and aiding the survival of nerve cells.
Studies have shown that people with Alzheimer’s disease have a reduced level of CRF.
Researchers used an experimental drug to prevent the hormone from binding to a brain receptor called CRFR1 in mice with Alzheimer’s disease that were free from memory impairments, therefore blocking the effects of the hormone.
They discovered that the mice had an abnormal stress response with reduced anxiety but increased behavioral inhibition when confronted by a stressful situation—in this case being placed in a new environment—and this is was due to the abnormal functioning of the CRFR1.
This abnormal stress response before the onset of symptoms may explain why people susceptible to stress are more at risk of developing Alzheimer’s.
Pardon and her team also found that interrupting the hormone from binding on to the CRFR1 receptor blocked the improvement of memory normally promoted by exercise. However, in mice with Alzheimer’s a repeated regime of moderate exercise restored the normal function of the CRF system allowing its memory enhancing effects.
The results are in line with the idea that regular exercise is a means of improving one’s ability to deal with everyday stress in addition to keeping mental abilities keen.
The switching on of this particular brain receptor during exercise increased the density of synapses, which makes the connection between nerve cells, the loss of which is thought to be responsible for the early memory loss seen in Alzheimer’s patients.
“This is the first time that researchers have been able to identify a brain process directly responsible for the beneficial effects of exercise in slowing down the progression of the early memory decline characteristics of Alzheimer’s disease,” says Pardon.
“Overall, this research provides further evidence that a healthy lifestyle involving exercise slows down the risk of Alzheimer’s disease and opens avenues for the new interventions targeting the altered CRFR1 function associated with the early stages of the disease.”
Research into Aging (Age UK) and the University of Nottingham funded the study.
The text of this article by Futurity is licensed under a Creative Commons Attribution-No Derivatives License. ᔥUniversity of Nottingham
In this video, Katherine “KC” Haydon, assistant professor of psychology and education at Mount Holyoke, discusses her research into how early life experiences — with parents, peers, and prior romantic partners — affect romantic relationships in adulthood.
Apparently not. With marriage proposals in the air around the new year, researchers at UC Santa Cruz report that both women and men tend to hold traditional views when it comes to marriage proposals.
Young adults were asked about their personal preferences for marriage traditions. Overwhelmingly, both men and women said they would want the man in a relationship to propose marriage. A substantial majority of women also responded that they would want to take their husband’s last name.
In fact, not one of 136 men surveyed believed “I would definitely want my partner to propose” and not a single woman said she “would definitely want to propose.”
“I was surprised at the strong the preference was,” said Rachael D. Robnett, a doctoral candidate in psychology at UC Santa Cruz. Robnett surveyed 277 undergraduates ages 17 to 26. She found that a substantial majority believes strongly that a man should propose marriage and a woman should take her husband’s name.
Robnett’s findings are reported in “Girls Don’t Propose! Ew” published in the January issue of the Journal of Adolescent Research. Robnett said she expected some preference for traditional engagement and marriage roles, but not at such a high level, particularly among young people. The survey was conducted in 2009-2010 among psychology majors or intended majors and was limited to heterosexual students.
“Given the prevalence of liberal attitudes among students at the university where data collection took place it is striking that so many participants held traditional preferences,” she writes. “Even more surprising is that many participants overtly state that their preferences were driven by a desire to adhere to gender-role traditions.” [continue reading…]
