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Credit: Sarchi

Different anti-aging treatments work together and add years of life

The combination of two neuroprotective therapies, voluntary physical exercise, and the daily intake of melatonin has been shown to have a synergistic effect against brain deterioration in rodents with three different mutations of Alzheimer’s disease.

A study carried out by a group of researchers from the Barcelona Biomedical Research Institute (IIBB), in collaboration with the University of Granada and the Autonomous University of Barcelona, shows the combined effect of neuroprotective therapies against Alzheimer’s in mice.

Daily voluntary exercise and daily intake of melatonin, both of which are known for the effects they have in regulating circadian rhythm, show a synergistic effect against brain deterioration in the 3xTg-AD mouse, which has three mutations of Alzheimer’s disease.

“For years we have known that the combination of different anti-aging therapies such as physical exercise, a Mediterranean diet, and not smoking adds years to one’s life,” Coral Sanfeliu, from the IIBB, explains to SINC. “Now it seems that melatonin, the sleep hormone, also has important anti-aging effects”. [continue reading…]

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When you rear-end the car in front of you at a stoplight, you may feel a mix of different emotions such as anger, anxiety, and guilt. The person whose car you rear-ended may feel angered and frustrated by your carelessness, but it’s unlikely that he’ll feel much guilt.

The ability to identify and distinguish between negative emotions helps us address the problem that led to those emotions in the first place. But while some people can tell the difference between feeling angry and guilty, others may not be able to separate the two. Distinguishing between anger and frustration is even harder.

In a study forthcoming in Psychological Science, a journal of the Association for Psychological Science, psychological scientist Emre Demiralp of the University of Michigan and his colleagues hypothesized that clinically depressed people would be less able to discriminate between different types of negative emotions compared to healthy individuals. Clinically depressed people often experience feelings of sadness, anger, fear, or frustration that interfere with everyday life.

“It is difficult to improve your life without knowing whether you are sad or angry about some aspect of it,” says Demiralp. “For example, imagine not having a gauge independently indicating the gasoline level of your car. It would be challenging to know when to stop for gas. We wanted to investigate whether people with clinical depression had emotional gauges that were informative and whether they experienced emotions with the same level of specificity and differentiation as healthy people.”

The researchers recruited 106 people between the ages of 18 and 40 to participate in their study. Half of the participants were diagnosed with clinical depression and half were not. Over the course of seven to eight days, they carried a Palm Pilot, which prompted them to record emotions at 56 random times during the day. To report their emotions, they marked the degree to which they felt seven negative emotions (sad, anxious, angry, frustrated, ashamed, disgusted, and guilty) and four positive emotions (happy, excited, alert, and active) on a scale from one to four.

Demiralp and his colleagues looked at participants’ tendency to give multiple emotions (e.g., disgusted and frustrated) similar rankings at a given point in time. According to their methodology, the more two emotions were reported together the less the person differentiated between these emotions.

The researchers found that clinically depressed people had less differentiated negative emotions than those who were healthy, supporting their hypothesis. Notably, they did not find the same difference between groups for positive emotions—people with and without diagnosed clinical depression were equally able to differentiate between positive emotions. It is possible that people who are clinically depressed differentiate more between positive emotions as a coping mechanism.

Demiralp and his colleagues argue that the procedure used in the study to record emotions may be particularly useful in studying the emotional experience of clinically depressed people, paving the way for more treatment and therapy options in the future.

“Our results suggest that being specific about your negative emotions might be good for you”, says Demiralp. “It might be best to avoid thinking that you are feeling generally bad or unpleasant. Be specific. Is it anger, shame, guilt or some other emotion? This can help you circumvent it and improve your life. It is one of our overarching goals to investigate approaches for facilitating this kind of emotional intelligence at a large scale in the population.”
Association for Psychological Science

Alzheimer logo
    Wear purple on Sept. 21, Alzheimer’s Action Day
    Speak up and fight stigma with

these tips

    Turn Facebook & Twitter purple by changing your profile picture to the END ALZ icon.

Right click on the END ALZ icon and save to your computer.

Log into your Facebook account. Move your cursor over your current profile picture and select “Change Picture.”

Use the browse function to locate and upload the END ALZ graphic.
 
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World Alzheimer Report 2012 reveals stigma and social exclusion are major barriers for people with dementia and their carers

  • 5% of people with dementia and 64% of family carers believe there are negative associations for those diagnosed with dementia in their countries
  • 40% of people with dementia report they have been avoided or treated differently
  • Report provides 10 key recommendations for governments and societies to include people with dementia into everyday activities

 
The latest World Alzheimer Report released today by Alzheimer’s Disease International (ADI) reveals that nearly one in four people with dementia (24%) hide or conceal their diagnosis citing stigma as the main reason. Furthermore, 40% of people with dementia report not being included in everyday life. What is startling is that nearly two out of three people with dementia and their carers believe there is a lack of understanding of dementia in their countries.
Alzheimers Disease International

Obama not born in USChildhood vaccines do not cause autism. Barack Obama was born in the United States. Global warming is confirmed by science. And yet, many people believe claims to the contrary.

Why does that kind of misinformation stick? A new report published in Psychological Science in the Public Interest, a journal of the Association for Psychological Science, explores this phenomenon. Psychological scientist Stephan Lewandowsky of the University of Western Australia and colleagues highlight the cognitive factors that make certain pieces of misinformation so “sticky” and identify some techniques that may be effective in debunking or counteracting erroneous beliefs.

The main reason that misinformation is sticky, according to the researchers, is that rejecting information actually requires cognitive effort. Weighing the plausibility and the source of a message is cognitively more difficult than simply accepting that the message is true – it requires additional motivational and cognitive resources. If the topic isn’t very important to you or you have other things on your mind, misinformation is more likely to take hold.

And when we do take the time to thoughtfully evaluate incoming information, there are only a few features that we are likely to pay attention to: Does the information fit with other things I believe in? Does it make a coherent story with what I already know? Does it come from a credible source? Do others believe it?

Misinformation is especially sticky when it conforms to our preexisting political, religious, or social point of view. Because of this, ideology and personal worldviews can be especially difficult obstacles to overcome.
Even worse, efforts to retract misinformation often backfire, paradoxically amplifying the effect of the erroneous belief.

“This persistence of misinformation has fairly alarming implications in a democracy because people may base decisions on information that, at some level, they know to be false,” says Lewandowsky.

“At an individual level, misinformation about health issues—for example, unwarranted fears regarding vaccinations or unwarranted trust in alternative medicine—can do a lot of damage. At a societal level, persistent misinformation about political issues (e.g., Obama’s health care reform) can create considerable harm. On a global scale, misinformation about climate change is currently delaying mitigative action.”

Though misinformation may be difficult to correct, all is not lost. According to Lewandowsky, “psychological science has the potential to counteract all those harms by educating people and communicators about the power of misinformation and how to meet it.”

In their report, Lewandowsky and colleagues offer some strategies for setting the record straight.

    Provide people with a narrative that replaces the gap left by false information
    Focus on the facts you want to highlight, rather than the myths
    Make sure that the information you want people to take away is simple and brief
    Consider your audience and the beliefs they are likely to hold
    Strengthen your message through repetition

 

Research has shown that attempts at “debiasing” can be effective in the real world when based on these evidence-based strategies.
The report, “Misinformation and its Correction: Continued Influence and Successful Debiasing,” is published in the September issue of Psychological Science in the Public Interest and is written by Stephan Lewandowsky and Ullrich Ecker of the University of Western Australia, Colleen Seifert and Norbert Schwarz of the University of Michigan, and John Cook of the University of Queensland and the University of Western Australia.

The report also features a commentary written by Edward Maibach of George Mason University.

The full report and the accompanying commentary are available free online.

Association for Psychological Science