Anxious girls’ brains work harder

This electrode cap was worn by participants in an MSU experiment that measured how people responded to mistakes. Female subjects who identified themselves as big worriers recorded the highest brain activity. Photo by G.L. Kohuth

In a discovery that could help in the identification and treatment of anxiety disorders, Michigan State University scientists say the brains of anxious girls work much harder than those of boys.

 
The finding stems from an experiment in which college students performed a relatively simple task while their brain activity was measured by an electrode cap. Only girls who identified themselves as particularly anxious or big worriers recorded high brain activity when they made mistakes during the task.

Jason Moser, lead investigator on the project, said the findings may ultimately help mental health professionals determine which girls may be prone to anxiety problems such as obsessive compulsive disorder or generalized anxiety disorder.

“This may help predict the development of anxiety issues later in life for girls,” said Moser, assistant professor of psychology. “It’s one more piece of the puzzle for us to figure out why women in general have more anxiety disorders.”

The study, reported in the International Journal of Psychophysiology, is the first to measure the correlation between worrying and error-related brain responses in the sexes using a scientifically viable sample (79 female students, 70 males). [continue reading…]

By Paul Frijters, University of Queensland and Tony Beatton, Queensland University of Technology

older happy overweight couple

Image: istockphoto

People are at their happiest at retirement age and their most miserable in their geriatric years, according to a study we published recently in the Journal of Economic Behaviour and Organisation. Our findings effectively debunk the myth of middle-aged blues and show how happiness levels vary widely over a person’s lifespan.

 

We all strive towards happiness to achieve a sense of fulfilment in our lives. But there is also an economic reason to advocate this goal. Happier people tend to be healthier than those who are unhappy; and mentally unhealthy people are costly.

According to the Department of Health and Ageing and beyondblue, depression treatment costs the Australian community more than $600 million each year. It’s expected depression will be second only to heart disease as the leading medical cause of death and disability within the next 20 years.

Existing ideas of happiness

The notion that happiness is U-shaped over a person’s lifetime has gained a lot of momentum over the past decade. The U-shape of the happiness myth goes something like this: we were happy in our youth, became more miserable in our mid-40s, only to have happiness return in our late-50s. We then confront an inevitable happiness decline as our health fails in our late-70s and beyond.

Previous research supporting the U-shape model of happiness incorrectly assumed that life factors (such as level of income, education, marital status and health) remained constant over a lifetime. And rather than following an individual over many years to see how happy they are at different ages, researchers studied various groups of people at different stages of their lives whilst inappropriate presuming they shared the same characteristics.

New research

Our research interrogated the U-shape of happiness theory by examining how happiness levels changed in a sample of 60,000 people in Australia, Britain, and Germany, over many years.

stooped old man

Happiness levels drop quickly as death approaches for people between the ages of 80 and 90. Flickr/rubybgold

We accounted for statistical limitations such as character traits and availability. This is important because being part of a study isn’t a random event: those who are busier (and perhaps happier in their middle-aged years) are less likely to take part in these studies. But happier (and therefore healthier) older people who have more time on their hands are more likely to be involved.

Hence the previous economic studies over-estimated the misery in mid-life and under-estimated it for very old people who were too sick to respond.

Unexpectedly, there was also the matter of increased honesty: Germans who were surveyed ten years in a row were significantly less happy than Germans interviewed at the beginning and end of the same period. The more a German talked, the unhappier she seemed to become; the dominant interpretation is that she became more honest about her true feelings and kept up a facade earlier on.

A similar thing occurs in Britain, but to a lesser degree. Australians had no such tendency. Correcting for both selectivity and dishonest reporting, we arrived at the wave-like profile below (click on the magnifying glass to zoom).

graph

A comparison of happiness in relation to age in Australia, Germany and Britain.

Our findings appear more in the line with the large body of psychological literature on the issue: there are no middle-age blues. Happiness is level through from about the age of 20 to retirement age (55 to 60), peaking at age 65 to 70 for Australians, then dropping increasingly fast as death approaches (80 to 90).

The same was found in Britain and Germany, though the happiness wave among the retired was far more pronounced there than elsewhere.

What’s next for happiness research?

One of the frontiers is how to promote happy personalities, which turn out to be extroverted personalities. Extroverts cope better with life shocks and are thus less stressed.

But how do we increase extroversion?

The short answer is we don’t know. Though the Penn Resiliency Program (PRP) of Professor Martin Seligman and his team at the University of Pennsylvania have been experimenting with telling school children how great they are, stimulating them to be open and extroverted. There are no results yet from these studies, but the idea is to look at whether we can educate children to be extroverted, and therefore happier, by stimulating their creativity and willingness to speak out.

Happiness policy is a relatively new concept in our society and we are only just getting used to the idea that it is something valid for our governments to worry about. We want our children to grow up as happy adults so we need to promote happy personality traits.

Meanwhile it is comforting to know that the happiest years come after retirement! Something to look forward to rather than dread.

Paul Frijters received ARC funding to do this work.

Tony Beatton does not work for, consult to, own shares in or receive funding from any company or organisation that would benefit from this article, and has no relevant affiliations.

The Conversation

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Alzheimer plaques in 3D

A virtual cut through the tomographic data set, reconstructed from phase-contrast measurements. The technique allows one to look inside the brain and see the plaques, without actually cutting the brain up into slices. (Figure: Paul Scherrer Institut/B. Pinzer)

Swiss researchers have succeeded in generating detailed three-dimensional images of the spatial distribution of amyloid plaques in the brains of mice afflicted with Alzheimer’s disease. These plaques are accumulations of small pieces of protein in the brain and are a typical characteristic of Alzheimer’s.

 
The new technique used in the investigations provides an extremely precise research tool for a better understanding of the disease. In the future, scientists hope that it will also provide the basis for a new and reliable diagnosis method. The results were achieved within a joint project of two teams of researchers – one from the Paul Scherrer Institute (PSI) and ETH Zurich, the other from the École Polytechnique Fédérale de Lausanne (EPFL). They have been published in the journal Neuroimage.

Alzheimer’s disease is responsible for about 60% to 80% of all cases of dementia. This disease affects people differently, but the most common initial symptom is the difficulty in remembering new information, because the disease first affects brain regions involved in the formation of new memories. Alzheimer’s dementia is characterized by typical brain lesions that spread to other brain regions as the disease progresses. One of these lesions, the so-called amyloid plaque, is composed of the accumulation of extracellular protein aggregates. These lesions appear early in the course of the disease and there is a high interest in detecting them in patients to diagnose or evaluate the progression of the disease. Recently, medical imaging methods have been developed and validated for this purpose. These allow regional amount of amyloid deposits to be measured, but individual plaques cannot be quantified. The latest results obtained by researchers from the Paul Scherrer Institute (PSI), ETH Zurich and the École Polytechnique Fédérale de Lausanne (EPFL) show that imaging single plaques is feasible under certain conditions. “This achievement could help to advance the development and evaluation of new imaging diagnostic markers for ultimately improving the diagnosis of Alzheimer’s disease,” explains Matthias Cacquevel, one of the authors at EPFL.

Paul Scherrer Institut (PSI)


 

Treating adolescents for major depression can also reduce their chances of abusing drugs later on, a secondary benefit found in a five-year study of nearly 200 youths at 11 sites across the United States.

Only 10 percent of 192 adolescents whose depression receded after 12 weeks of treatment later abused drugs, compared to 25 percent of those for whom treatment did not work, according to research led by John Curry, a professor of psychology and neuroscience at Duke University.

“It turned out that whatever they responded to — cognitive behavioral therapy, Prozac, both treatments, or a placebo — if they did respond within 12 weeks they were less likely to develop a drug-use disorder,” Curry said.

The study found no such relationship when it came to thwarting alcohol abuse, however.

The researchers followed nearly half the 439 participants from the “Treatment for Adolescents with Depression Study” (TADS; 2000-2003), led by Dr. John March, chief of Child and Adolescent Psychiatry at Duke University Medical Center. TADS is considered the largest sample of adolescents who had been treated for major depression. (https://trialweb.dcri.duke.edu/tads/overview.html)

The participants analyzed by Curry’s study were ages 17-23 at the end of the five-year follow-up study and had no preexisting problems with abusing alcohol or drugs.
[continue reading…]