New discoveries on depression

depressed woman

Image: iStockphoto

During depression, the brain becomes less plastic and adaptable, and thus less able to perform certain tasks, like storing memories. Researchers at the Swedish medical university Karolinska Institutet have now traced the brain’s lower plasticity to reduced functionality in its support cells, and believe that learning more about these cells can pave the way for radical new therapies for depression. “We were able to cure memory dysfunction in ‘depressed’ rats by giving them doses of D-serine,” says Mia Lindskog, biologist and Assistant Professor at Karolinska Institutet’s Department of Neuroscience.

Dr Lindskog and her team used FSL rats, which are rats that have been specially bred with a disposition for ‘depression’. The rats were first put through two tests to confirm that they had the symptoms that are also characteristic of human depression. In the first, the rats’ memories were checked by repeatedly being exposed to different objects; in the second, the team assessed their level of apathy by releasing them in a container of water and observing whether they merely stayed floating in the container or immediately tried to climb out (non of the rats had to stay in the water for more than five minutes). In both cases the FSL rats’ results were compared with normal laboratory rats, and memory disorders and apathy could be confirmed.

The researchers then injected the rats with D-serine. This substance improved their memories but had no effect on the apathy. “We have shown that there are two symptoms here that can be influenced independently of one another, which means they could be treated in tandem in patients with depression,” says Dr Lindskog. The researchers also studied the synaptic activity in the hippocampus of the rats, a part of the brain which plays an important part in the memory. [continue reading…]

Stress Changes How People Make Decisions

overworked manTrying to make a big decision while you’re also preparing for a scary presentation? You might want to hold off on that. Feeling stressed changes how people weigh risk and reward. A new article published in Current Directions in Psychological Science, a journal of the Association for Psychological Science, reviews how, under stress, people pay more attention to the upside of a possible outcome.

It’s a bit surprising that stress makes people focus on the way things could go right, says Mara Mather of the University of Southern California, who cowrote the new review paper with Nichole R. Lighthall. “This is sort of not what people would think right off the bat,” Mather says. “Stress is usually associated with negative experiences, so you’d think, maybe I’m going to be more focused on the negative outcomes.”

But researchers have found that when people are put under stress—by being told to hold their hand in ice water for a few minutes, for example, or give a speech—they start paying more attention to positive information and discounting negative information. “Stress seems to help people learn from positive feedback and impairs their learning from negative feedback,” Mather says. [continue reading…]

Do antidepressants work? Since the introduction of Prozac in the 1980s, prescriptions for antidepressants have soared 400 percent, with 17 million Americans currently taking some form of the drug. But how much good is the medication itself doing? “The difference between the effect of a placebo and the effect of an antidepressant is minimal for most people,” says Harvard scientist Irving Kirsch. Will Kirsch’s research, and the work of others, change the $11.3 billion antidepressant industry? Lesley Stahl investigates. Read Story: Treating Depression: Is there a placebo effect?

Caution If you are depressed you should see your doctor. If you are already on Anti-depressants you should not stop taking them

Source: CBS News

young people drinking alcohol

Nearly two in three youngsters underestimated the unit content of their drinks
Image: istockphoto

Anew University of Sussex-led study reveals that many young people do not have the knowledge or skills to keep their drinking within guidelines on sensible consumption.

According to research led by Dr Richard de Visser, a senior lecturer in psychology at Sussex, young people are highly likely to underestimate their own consumption of alcohol units, even if they have some knowledge of government guidelines.

The study, which is published in Drug and Alcohol Review, involved surveying 18 to 25-year-olds about their knowledge and beliefs about safe drinking. The participants were then asked to pour their “usual” measure of a drink (wine, beer or vodka), followed by what they believed to be a “unit” of that particular drink.

The researchers found that the “usual” drinks were substantially larger than one unit, as set by government guidelines, with nearly two thirds of participants underestimating the unit content of the drinks they had poured.

In the survey, which tested knowledge of the government’s guidelines about alcohol consumption, fewer than half the respondents gave correct responses to five of the seven questions, although most were able to correctly state the recommended daily units for men and women.

“Our results indicate that young people tend not to possess the knowledge and or skills required to drink alcohol in accordance with government guidelines,” says Dr De Visser. “Using drink-pouring tasks as part of this education could promote better understanding of alcohol units and more accurate reporting of alcohol consumption.”

However, he acknowledges that the success of getting the message across to young drinkers depends on how motivated they are to take in the information.

“Many other studies have shown that young people are less concerned about the health issues of drinking and more interested in the pleasure it gives them. Moderation and restraint runs counter to the contemporary cultural emphasis of excessive and conspicuous consumption.”

Source: University of Sussex
Further reading: The UK government’s guideline for “sensible drinking”